細胞衰老是細胞停止分裂的現象。衰老可由內部（氧化應激、DNA損傷等）和外部（毒素、紫外線等）因素誘導。衰老是一種生長停滯的狀態，細胞在這種狀態下保持活力但停止分裂。衰老細胞表現出細胞大小增加，β-半乳糖苷酶、p53和P16活性的衰老相關表達，以及基因表達模式的改變。
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SenTraGor™ (GL13) is an innovative reagent for the detection of senescence. Senescent cells play a potent role in normal development, tissue homeostasis, aging and a wide spectrum of age related disorders. Up to now, a major problem in the field of senescence was the absence of a reliable marker to specifically detect these cells, especially in situ. SenTraGor™ (GL13) is a biotinylated Sudan Black B based chemical reagent that was designed to overcome this constraint.
SenTraGor™ (GL13) staining allows the detection of senescence in any biological material. Direct visualization of senescent cells can be achieved in all archival tissue specimens (formalin-fixed paraffin-embedded) and cells from biopsies or cell cultures.
